AlphaGenome (Google DeepMind, Nature 2026) predicts how DNA sequence controls gene regulation—including chromatin accessibility, transcription factor binding, histone modifications, gene expression, splicing, and 3D genome structure—at single-base-pair resolution from a 1 Mb input. A key use case is interpreting noncoding variants to predict their functional impact before performing laboratory experiments.

Topics include:

• What AlphaGenome predicts and how it compares with prior models (Enformer and Borzoi)
• Research applications, including variant interpretation, experimental design, and integration with existing Astrocyte workflows (Parabricks → AlphaGenome → AlphaFold3)
• A conceptual overview of how the model works
• Live walkthrough: obtaining an API key and making your first prediction

AlphaGenome is already available through Astrocyte. Access is free for non-commercial research.

Instructor: Dr. Xin Yang

Date: Wednesday, July 8, 2026

Time: 10:30 AM

Location: G9.102A or hybrid Directions to G9 conference rooms-G9250A-G9102.pdf

Teams link: Click here to join the meeting

Registration: not necessary, feel free to walk in

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