UT Southwestern Events Calendar

Department of Biophysics December Seminar Series: “Proteostasis function and disfunction: the folding machines that maintain proteome health”

Judith Frydman, PhD., Professor of Biology and Genetics at Stanford University in Standford, CA

Dr. Frydman is originally from Argentina, where she majored in Chemistry and received her PhD in Biochemistry from the University of Buenos Aires. Her postdoctoral training with Ulrich Hartl led to three major contributions to the field of cellular protein folding: (i) the discovery of the eukaryotic chaperonin complex TRiC; (ii) the discovery that polypeptides fold cotranslationally as they emerge from ribosomes; (iii) the discovery that molecular chaperones are specifically recruited to bind ribosome-nascent chain complexes.

Her independent research at Stanford University continues to define key principles of proteostasis in eukaryotic cells. Her discovery that distinctly regulated protein homeostasis networks mediate cotranslational folding and protection of the proteome from proteotoxic stress defined the underlying logic of chaperone networks. The Frydman lab also uncovered that proteome quality control relies on spatial sequestration of misfolded and aggregated proteins in specific cellular compartments, mediated by chaperone-dependent pathways cooperating with components of the ubiquitin-proteasome system. These insights have important implications to understand and treat aging-linked neurodegenerative diseases and other misfolding-associated maladies.

Thursday, December 12, 2019 at 12:00pm to 1:00pm

T. Boone Pickens Biomedical Building (ND), ND13.218
6001 Forest Park Road, DALLAS, TX, 75390

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