Anthony Fitzpatrick, PhD., Assistant Professor of Biochemistry & Molecular Biophysics at Columbia University in New York, NY
In the Fitzpatrick Lab, we leverage the latest developments in cryo-electron microscopy with complementary biophysical techniques (proteomics, light-microscopy, microfluidics) to explore the molecular and structural basis of neurodegeneration. To this end, we determine the structure and behavior of amyloid fibrils, purified directly from postmortem brain tissue, that are implicated in a range of neurodegenerative diseases. Additionally, we aim to understand the role of protein aggregation in vivo by visualizing the cellular changes that occur in response to the formation, clearance and spread of fibrillar inclusions using light-microscopy and cryo-electron tomography.
Thursday, October 10 at 12:00pm to 1:00pm
T. Boone Pickens Biomedical Building (ND), ND13.218
6001 Forest Park Road, DALLAS, TX, 75390
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