"Targeting BMP, Activin, and TGF Beta Signaling in Pulmonary Hypertension: Lessons from Human Genetics, Disease Models and Clinical Trials"

The Robert L. Johnson, Jr., M.D. Lectureship in Internal Medicine

Speaker:

Paul B. Yu, M.D., Ph.D.
Associate Professor of Medicine
Division of Cardiology
Director, MGH Cardiovascular Research Center
Massachusetts General Hospital and Harvard Medical School

About Paul Yu:

Dr. Yu holds a bachelor's degree in biological sciences from Stanford University. He received his medical and doctoral degrees from Duke University. He then completed internal medicine residency training at the University of California San Francisco, followed by clinical and research fellowships in cardiovascular disease at Massachusetts General Hospital.

Dr. Yu's laboratory studies the role of cytokine growth factor signaling in cardiovascular homeostasis, injury repair, and regeneration. Specifically, the laboratory has devised novel models, molecular tools, and pharmacologic probes for examining the function of bone morphogenetic protein (BMP), activin, growth and differentiation factor (GDF), and transforming growth factor-beta (TGF-b) signaling in cardiovascular and musculoskeletal development and function. A major focus of his laboratory’s work is to discern how BMP/TGF-β signaling achieves spatio-temporal and functional specificity for developmental patterning, and to modulate the tissue-specific consequences of inflammation and injury. Dr. Yu’s clinical and translational interests include pulmonary vascular disease, cardiovascular rheumatology, and fibrodysplasia ossificans progressiva.